Epilepsy is a neuropsychological disorder which causes seizures to occur due to over discharge of neuro transmitter substances result into an imbalance between excitatory and inhibitory neurotransmitters. In the present study, antiepileptic activity of Tabernaemontana divaricata leaves extracts viz: aqueous and ethanolic at different doses (50, 100 and 150 mg/kg, i.p.) were studied on electrically and chemically induced seizures. Among the extracts of Tabernaemontana divaricata, ethanolic extract shows a significant (P<0.01) anti seizure properties while aqueous extract did not show any significant contribution to reduce the seizure in both PTZ and MES induced seizures. Thus the present study reveals the anticonvulsant activity of Tabernaemontana divaricata evaluating the traditional folklore medicinal use of the plant.
