Anticonvulsant activity of some mannich bases of 2-aminothiophenes having indole-3-carboxaldehyde in mice was assessed using Strychnine, Picrotoxin animal models. The lithium-pilocarpine model of status epileptics was also used to assess the anticonvulsant activity in rats. Compound II have shown good activity, compound I, III, IV, V have shown moderate activity against the standard drugs. The dose of 100mg/kg afforded protection to all animals.
