This study is aimed at accessing the antibacterial activity of some medicinal plants against extended spectrum betalactamase producing enterobacteriaceae that are prevalent in Calabar hospitals. Aqueous leaf extracts ofEditan (Lasiantheraafricana),Ikongetidot (Veroniaamygdalina) and Atama (Heinsiacrinata) were used for the ESBL testing. Ikongetidot (Veroniaamygdalina) showed significantly highest antibacterial activity against extended spectrum beta-lactamase producing E. coli and K. pneumonia (17mm-16mm) respectively, but also significant against proteus. While Editan (Lasiantheraafricana) and Atama (Heinsiacrinata) showed least antimicrobial activity against all the test organisms. Aqueous extracts of Ikongetidot produces largest zones of clearance on E.coli, K. pneumonia, and Proteus mirabilisfollowed by Editan and atama, prodicng a statistically different (p<0.5) values. These findings present supports for the possible use of the aqueous extract of IkongEtidot, Editan and Atama for the detection of ESBL producers from clinical isolates.
