Morinda citrifolia L. is one of the most important traditional polynesian medicinal plant. This small evergreen tree is native of South Eastern Asia to Australia and now it has pantropical distribution all over the world. This plant has antifungal, antibacterial, anti-inflammatory and antiviral activities. During the present study, a preliminary study pertaining to hydro-alcoholic extraction of leaf extract of Morinda citrifolia was carried out since this method is more suitable in comparison to methanol or water extracts for clinical study. The hydro-alcoholic leaf extract was prepared by soxhlet extraction method and it was assessed with two antibiotics in-vitro using disc diffusion method against six different bacterial pathogens. In the antibacterial analysis, Staphylococcus aureus was found more susceptible followed by Pseudomonas aeruginosa and Bacillus subtilis towards the hydro-alcohol extract. The Amoxyclav drug was found to be impotent in order to control the growth of all bacteria but Rifamycin had good control over the pathogens. Hydro-alcoholic extract was observed the suitable drug than the amoxyclav in the present study. The results revealed that plant extracts have inhibitory activity against the tested organisms.
