Mycoplasmas possess remarkable immunoregulatory properties and can potentially establish chronic latent infections with little signs of disease. Morinda citrifolia (noni) is largely used in traditional medicine. It was also reported that noni juice is typically applied for the treatment of cutaneous infections. In recent years, multiple resistances in human pathogenic microorganism have developed due to the indiscriminate used of antibiotic drugs commonly employed in the treatment of infectious diseases. The objective of the study was to evaluated antibacterial activity of the fruit juice of M. citrifolia against medically important mycoplasma. M. citrifolia fruit juice was subjected to screening against Mycoplasma pneumoniae, Mycoplasma penetrans and Mycoplasma fermentans. The antibacterial activity was assessed by the presence or absence of growth. M. citrifolia fruit juice produced the highest antibacterial activity against mycoplasmas tested. The activity of 100% fruit juice indicates that the active components are concentrated in this fraction. This it is the first report of antibacterial activity of M. citrifolia fruit juice against medically important mycoplasmas in comparison with other microorganisms.
