Cold ethanol extracts of some medicinal plants, collected from Panchet and Panchokot hills, have been prepared and antibacterial study of the extracts have been performed by the filter paper disc method against Staphylococcus aureus (Gram positive bacteria) and Escherichia coli (Gram negative bacteria). The method is based on the diffusion of an antibiotic from a filter paper disc through the solidified culture media of a Petri dish used for study. Besides, the presence of different classes of chemical compounds in each extract has been detected.