The present study describes the antimicrobial activity of floral extracts of Crossandra infundibuliformis and Jasminum sambac against cell phone bacteria. The cell phone is a basic tool of technology in our modern lifestyle. It harbors a good breeding ground for various micro organisms. It is an exogenous source of nosocomial infections. The cell phone serves as a mechanical vector for the transmission of various potential pathogens. The mixed aerobic bacteria present on the surface of cell phone were isolated. The antimicrobial activity of aqueous extracts of inflorescence of Crossandra infundibuliformis and Jasminum sambac were assessed against the isolated cell phone bacteria. The floral extract demonstrated antimicrobial activity and decreased the count of cell phone bacteria on the surface of the handset. Antimicrobial wet wipes were prepared from cellulosic paper and floral extracts and they demonstrated high efficacy in reducing cell phone bacteria