This study evaluated antibacterial activities of bacterial symbionts of soft corals from the water of Wai-Sai Island, Papua. The soft corals collected namely Sarcophyton sp, Sinularia sp and Lobophyton sp associated bacteria were found to have antibacterial activity. Antibacterial activity was determined by disc diffusion method against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Bacillus subtilis. The results of this study indicated that there were 98 isolates collected from soft corals and two isolates from Sinularia sp associated bacteria RA 4.2 and RA 2.2 were found to inhibit the growth of S. aureus, E. coli, K. pneumonia and B. subtillis.
