Nyctanthes Arbor tristis and Maharasnadi ghan extracts were studied for arthritis using gouty arthritis and Freund’s adjuvant Induced Polyarthritis. The plant was evaluated for acute toxicity studies at two different dose levels and it did not show any toxic or deleterious effects indicating low toxicity of the extracts even at high doses. In gouty arthritis a significant reduction in legged gait was observed as compared to control group whereas in poly arthritis model complete control was noticed in injected as well as uninjected paw. Significant reduction reduction in the elevated levels of serum lysosomal enzymes (SGPT, SGOT, and ALP) and lipid peroxidation was noted as compared to control group. The extracts enlighten the probable role in both acute and chronic arthritis models suggesting further histopatholgical studies are necessary to establish its anti-arthritic potential. The extracts of the plant in the formulation might be containing significant amount of flavonoids which might had played a good evaluator parameter in reduction of the inflammation and thereby reducing legged gait. In vision of further studies the extracts needs to be studied in details by focusing on histopathogical examinations.
