Angiogenesis is one of the important hallmarks of cancer that include both cancer progression and metastasis.
The recent advances in natural product research stread light on identification and isolation of non-toxic antiangiogenic
and antitumor compound from natural source. In current study, our team made an attempt to evaluate
the anti-angiogenic activity of various crude extracts of Moringa oleifera Lam leaves. The extracts were prepared
by successive soxhlation and the anti-angiogenic activity was evaluated by employing in vivo CAM assay model.
The test extracts were administered at 1, 10 & 100 μg doses and percentage inhibition of neovascularization was
observed after 48 h. Among all the extracts, ethyl acetate extract of Moringa oleifera Lam at a dose of 100 μg showed
significant inhibition of neovascularization (70%) when compared with other extracts.
