Aqueous extracts of leaves of Sauropaus Androgynous was examined with different in vitro test including diphenly picryl hydrazyl radical scavenging, lipid peroxidation, superoxide anion radical scavenging and reducing power. Aqueous extract showed IC 50 1.5 mg/ml on DPPH radical scavenging and 0.4mg/ml to lipid peroxidation of microsomes isolated from rodent liver homogenate induced by the Fecl2- H2O2. Superoxide anion and reducing power showed IC 50 of 0.5 mg/ml, 1.2 mg/ml respectively. Further aqueous extract showed cytoprotective effect against xenobiotic-induced (CCl4) oxidative stress in yeast cells. The level of Reactive oxygen species, Lipid peroxidation (TBARS) and Lactate dehydrogenase (LDH) generated was significantly lowered in cells treated with extracts along with xenobiotic compared to that of xenobiotic induced cells alone
