Coccinia indica is a creeper locally available plant and upon literature survey revealed that it is used in conditions rheumatism, kidney problems, chronic bronchitis, arthritis and in obesity. Hence this present study was aimed to explore the anti obesity activity of fruit extracts i.e. alcoholic (ALFCI) and aqueous (AQFCI) in Cafeteria diet (CD) and Atherogenic diet (AD) induced obesity models in experimental animals i.e. female rats. Standard reference Sibutramine (5 mg/kg) produced a significant (P<0.01) anti obesity activity in CD and AD induced obesity in rats. Both ALFCI and AQFCI with medium (200 mg/kg) and high doses (400 mg/kg) exhibited a significant (P<0.01) anti obesity activity by reducing the body weight, food intake, organ and fat pads weight and serum GLU, CHO, TRG, LDL and VLDL cholesterol levels with an increased HDL levels in CD and AD induced obesity models in female rats.
