Methanolic extract from the whole plant of the Leptadenia Pyrotechnica were investigated for their anthelmintic activity against Pheretima posthuma. Two concentrations (50 and 100 mg/ml) of methanolic extract were studied in activity, which involved the determination of time of paralysis and time of death of the worm. Methanolic extract exhibited significant anthelmintic activity at highest concentration of 100 mg/ml. Albendazole in 20mg/ml concentration as that of extract was included as Standard reference and CMC (0.5% as control) The anthelmintic activity of alcohol and aqueous extracts of Leptadenia Pyrotechnica has therefore been demonstrated for the first time.