This paper describes the analytical method suitable for validation of Piroxicam by reversed Phase High Performance liquid chromatography (RP-HPLC) method. The method utilized RP-HPLC (Water 2695 with PDA detector) model and a column, 150mm ´ 4.6 mm, 5m (Inertsil, ODS- 3V, 150mm ´ 4.6mm, 5m). The mobile phases were comprised of A, B of Methanol and Buffer pH 3.0 (55:45v/v). Validation experiments were performed to demonstrate System suitability, precision, linearity and Range, Accuracy study, stability of analytical solution and robustness. The method was linear over the concentration range of 5- 150 mg/ML-1. The method showed good recoveries (98.0 – 99.8%)
