The dry leaves of Pongamia pinnata Linn. is used in traditional medicines for the treatment of diarrhoea, diabetes and inflammatory disorder. In the present study, we investigated the analgesic activity of the standardized ethanolic extract was evaluated for its in-vivo analgesic activity by using the Eddy’s Hot plate method in mice. In both of the cases Diclofenac sodium was used as standard drug. The extract at the doses of 250 and 500 mg/kg elicited a significant analgesic activity in a dose-dependent manner by using Eddy’s Hot plate method. The analgesic mechanism of activity of the standardized ethanolic extract of P. Pinnata Linn. pain mediators may be the main mechanisms of action of P. Pinnata ethanolic extract.
