Oxidative stress occur in several diseases such as cardiovascular disease, diabetes, cancer, aging and Alzheimer's disease. Cardiac arrhythmia is today a common clinical problem presenting with decrease, increase or mismatch in normal heart rhythm that cause reduction in cardiac output. Given the importance of heart diseases and noting that in many countries, cardiovascular diseases are among the top causes of death and the leading cause of disability and the fact that application of medicinal plants and herbal medicines is common in the treatment of hypertension, ischemic heart disease, congestive heart disease, arrhythmias and angina pectoralis, therefore, this review aimed to identify the anti-arrhythmic medicinal plants indigenous in Iran. Due to the proven anti-arrhythmic effects of medicinal herbs including grape, sour orange, olive, pokeweeds and nettle and regarding the obvious phytochemical agents in them, so hesperidin, naringin, deosepyn, apigenin, aloroporin and hydroxytyrosol, phytolactosin, catechins, betacianin, tannins and free phenolic acids can be used as anti-arrhythmic ingredients used for the production of bioactive agents.
