Shorea tumbuggaia Roxb belonging to the family Dipterocarpaceae, is a globally threatened medicinal tree taxa is valued for its timber and pharmaceutical properties. Present work is focused on screen secondary metabolites; antiinflammatory and anti-nociceptive effects on the leaves extract of Shorea tumbuggaia Roxb were examined. Acute toxicity studies were performed as per OECD guide (line no.420 & 423) and method of CPCSEAfor the methanolic and hydro alcoholic extracts and it was concluded that both the extract showed no toxicity effect upto 3.5gm/kg body weight. The anti-inflammatory activity was performed by using formalin-induced sub plantar region of right hind paw edema model and anti- nociceptive activity was performed by hot plate and acetic acid induced writhing method. Diclofenac sodium (DS) was used as a positive control; significant reduction in the inflammation and pain were observed which indicate that the Shorea tumbuggaia Roxb leaves extract possess anti-inflammatory and antinociceptive. Phytochemical studies indicate that flavonoids, anthocyanins, tannins, saponins and phenols were the major component in the methanolic extract. Although existence of anti-inflammatory and anti-nociceptive activity, suggest a NSAID-like mechanism. Hence further investigation on the separation and isolation of active principle will lead to a potent anti-inflammatory and anti- nociceptive agent.
