The purpose of this research was to study the relationship between hardiness and mental disorders among male and female payame-noor university students. Forty one students (19 male and 21 female) were selected randomly. Ahwaz Hardiness Scale (AHS) and SCL-90-R questionnaire were used to carry out the study. The results of the study showed that there is a negative correlation between hardiness subscales and mental disorders. Regression analysis also showed that subscales commitment and control can predict 62% mental disorders. Challenge subscale and total hardiness have no power of prediction on mental disorders.