The aim of the present study was to investigate the effects of CMS (chronic mild stress) on serum lipids,whichmay be ininteraction with stress or depressive disorders.Forty to forty-five- day- old laboratory rats were assigned to two groups; control (n: 10) and CMS (subjected to CMS procedure, n: 30). Rats in the control group were reared in single cages without any environmental stress. Rats in CMS were entered the CMS procedure. This protocol consisted of mild unpredictable stressors (intermittent illumination, stroboscopic light, grouping, food or water deprivation, exposure to an empty water bottle, solid cage, cage tilting, etc.). Later, CMS protocol sucrose preference (SP) test was used for the identification of depressed animals. Rats with SP lower than 65% were defined as depressed animals. Blood serum was taken from two groups (control and CMS) for the determination of blood lipids by Elisa kits.The analyzed data showed that serum lipids including total cholesterol, triglyceride, HDLcholesterol and LDL-cholesterol didn’t lead to a significant difference between two experimental groups. We concluded thatCMS- induced depression cannot affect serum lipid profile in rat model. Further studies with different protocol of depression are required for the identification of possible relations of depression and lipid metabolism.
