A new series of 1,2-diazaphenanthrene derivatives 3a-p has been synthesized and subjected to
evaluate their antibacterial properties. All the synthesized compounds of the series elicit
remarkable activity in comparison to standard drug (ampicillin). A number of descriptors were
tested to adjudge a quantitative correlation between activity and structural features. However,
significant correlation has emerged between activity and physicochemical parameters viz.
hydrophobic parameter (log P). Moreover, results are interpreted on the basis of multiple
regression analysis and cross-validation methodology.
