The research was set to assess the diuretic effect of V. amygdalina extract on Wistar rats. Assessment of diuresis was carried out on five group of rats. Three groups were injected intraperitoneally with varying concentrations of V. amygdalina extract in normal saline, each group consisting of eight rats. Groups iv and v were injected with furosemide (0.1mg/100g body weight) and saline respectively. The dosage of extract administered to groups i, ii, iii iv and control are 25,50,75, 0.1(furosemide) and 0 mg/100g body weight, while the mean urine outputin ml/rat/hourfor groups I to v are 1.050± 0.064, 1.285±0.079,1.465±0.055, 4.621±.319 and 0.95±0.045 resp ectively. A statistically significant difference was observed when the urine output of groups i, ii and iii and iv were compared to that of the control group. These values reveal a fairly proportionate increase in urine output in response to increasing dosage of extract.V. amygdalinaaqueous extract perhaps possess a dose dependent diuretic property due to the presence of phytochemical diuretic factor(s)/principle(s) which, if properly harnessed,can be used in the treatment of retentive disorders of water metabolism.
