Der Pharmacia Lettre
Abstract
Author(s): Mradul R. Gupta, Rahul Kapoor, M. S. Sudheesh, Umesh K. patil
Microencapsulation may be defined as the process of surrounding or enveloping one substance within
another substance on a very small scale, yielding capsules ranging from less than one micron to several
hundred microns in size. Drug discovery and delivery to retard the degeneration of joint tissues
are challenging. Current treatment of different arthritis involves administration of ideal nonsteroidal
anti-inflammatory drugs (NSAIDs) mainly by oral and parenteral route. Frequent
dosing of NSAIDs often leads to patient non compliance. Accounting this problem, drug delivery
technologies should be developed which are reduces frequency of dosing along with sustained
release of medicament. Among several novel drug delivery systems microencapsulation is one of
the novel plot form technology employed to sustain the drug release and reduce or eliminate
gastrointestinal irritation, dose intake and ultimately improve the patient compliance in the
pharmacotherapy of arthritis, This review reports a comprehensive overview of newly developed
microencapsulation technologies as therapeutic targets of arthritis which are may be potentially
to reduce adverse side effects induced by NSAIDs.
