In order to investigate the effects of aerobic plus resistance training as part of a long-term interdisciplinary therapy on pro-anti-inflammatory biomarkers in obese adolescents, a total of 86 obese adolescents (42 in bicycle and 44 in treadmill training groups) were enrolled for 1 year of interdisciplinary weight-loss therapy.The most important finding was that Δ submaximum and maximum oxygen consumption (VO2) was inversely correlated to Δ leptin/adiponectin ratio in obese adolescents after weight loss intervention. In addition, both groups presented significant reduction in thepro-inflammatory biomarkers leptin and leptin/adiponectin ratio. Also, an increase of adiponectin, adiponectin/leptinratio was observed. In conclusion, aerobic plus resistance training as part of a longterm interdisciplinary therapy was effective in improving pro-anti-inflammatory adipokines in obese adolescents. Additionally, the improvement of work capacity and physical fitness observed contributed directly to the improvement of pro-anti-inflammatory biomarkers and may also contribute to enhance exercise tolerance in obese adolescents.
