Diversified actinomycete species were isolated from coal fields of Andhra Pradesh and dominant
genera were separated. A total of eleven antibiotic microbial producers have been isolated from
the coal soil, five of them have shown activity against both Gram-positive and Gram-negative
bacteria. On the other hand, six isolates were only active against Gram-positive bacteria. They
exhibited resistance to ampicillin, tetracycline, rifampicin, methicillin, streptomycin,
streptothricin and chlorotetracycline and taken HIV-drugs like Lamostad-N-30, Trimune-30,
zidovudine contain L = Laminarin, S = Stavudine and n = nevirapine but slight resistance factor
identified by HIV-drugs against mandamarri strain of coal site of Andhra Pradesh. Metabolites
produced by the strain showed good antimicrobial activity against Gram-positive and Gramnegative
bacteria.
