Der Pharmacia Lettre
Abstract
Author(s): Shalini Tripathi
Hydroalcoholic extract of fruits of Nyctanthes arbor-tristis Linn (NATEF) was pharmacologically validated for its
antiagressive properties in experimental animals using various models such as Foot shock-induced aggression,
Isolation-induced aggression, Resident-intruder aggression and Water competition test. Extract was given orally at
two different dose levels (250 and 500 mg/kg) once daily for three consecutive days, while Diazepam (2.5mg/kg),
was administered as positive control. NATEF (250 and 500mg/kg) on all the models produced significant
antiagressive effects such as a reduction in vocalizations along with lowering of leaping, running, rearing and
facing each other, increased latency time to first attack, reduced spout gaining frequency along with a reduction in
time spent which was found to be statistically significant compared to the control .Results suggested that NATEF
showed significant antiagressive activity.
