The present study has been designed to determine the role of leaf and seed ethanol and aqueous extracts of Tribulus terrestris, Convolvus arvensis, Malva parviflora, Melilotus indicus, Rumex chalepensis and Anchusa arvensis for potential antibacterial activity, if any, against two Gram-positive include Staphylococcus aureus NCTC7428 Bacillus subtilis MTCC 441 and four Gram-negative include Pseudomonas aeruginosa MTCC 2453, Escherichia coli MTCC 739, Enterobacter aerogenes ATCC 13048and Klebsiella pneumoniae MGH 78578 pathogenic multi-drug resistant bacteria. The MIC values of both aqueous as well as alcoholic leaf and seed extracts of the plants have been determined for each microorganism and compared with standard antibiotics of β- lactams, flouroquinolones, tetracyclines and aminoglycosides.