Electrochemical methods have been widely used for the determination of electro active compounds due to their simplicity, sensitivity, stability, and low cost. A carbon paste electrode was used for the electro analytical determination of ampyrone in real sample by cyclic, linear sweep and differential pulse voltammetric techniques. The oxidation of ampyrone was irreversible and exhibited a diffusion controlled process. The oxidation mechanism was proposed. The dependence of the current on pH, the concentration and scan rate was investigated to optimize the experimental conditions for the determination of ampyrone. It was found that the optimum pH for the determination of ampyrone was 3.0. The current measured by differential pulse voltammetry presents a good linear property as a function of the concentration of ampyrone in the range of 1.0x10-8 to 1.0x10-6 with a limit of detection 0.102 x 10-9 M. In addition, the reproducibility, precision and accuracy of the method were checked as well. Electro analytical determination of ampyrone in human urine and plasma samples was carried out using differential pulse voltammetry. The method finds its applications in quality control laboratories.
