Peganum harmala. belongs to Asian Origin and grows in the Middle East and in part of South mainly in India and Pakistan, is a plant of the family Nitrariaceae. It is a perennial plant which can grow to about 0.8 m tall. The aim of this study is to overview its therapeutic effects than its nutritive and industrial effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases up to 2016.totally, of 85 found articles, 40 articles were included. The search terms were “Peganum harmala.”, “therapeutic”, “pharmacological”. Various studies have shown that Peganum harmala. possess Candidiasis ,Biological ,Anti- cholinesterase, Anti- tumor angiogenesis, Antiparasitic effect, Anti-inflammatory effect, Cerebroprotective effect, Cytotoxicity effect, Antioxidant effect ,Hepatoma cancer effect, AhR ligands-mediated effects, Hepatoprotective prevention effect, Hypoglycemic effect, Pesticide effect, Antibacterial effect, Theileriosis effect, Antimicrobial effect, Analgesic effect, Histo-functional effects, Antinociceptive effects ,Antitumor effect, Haemosporidian infections in cattle effect, Haemosporidian infections effect, Abortificient potential effect. Peganum has different properties and combinations and numerous medicinal properties of its extract, essential oils, its stems and leaves require more research about the other beneficial and unknown properties of this plant.
