Here we present the results of the search for relationships between electronic structure and two biological activities of a group of 1,7-bis-(aminoalkyl)diazachrysene derivatives: the percentages of inhibition of the Botulinum neurotoxin serotype A light chain and the antimalarial activity against three P. falciparum strains. In the case of inhibition of the Botulinum neurotoxin serotype A light chain the results show that the aromatic system is involved in the inhibitory process. There is indirect evidence that one or both side chains could participate in the inhibitory process. In the case of antimalarial activity, the side chains and the aromatic system participate in the process. The antimalarial mechanisms seem to be the same for the three strains. Some suggestions are made to modify these compounds to enhance both activities.
