cost effective first derivative spectrophotometric method was developed to determine linagliptin in combination with empagliflozin and metformin either in bulk or in different marketed formulations, namely Tradjenta®, Jentadueto® and Glyxambi® tablets. Determination of linagliptin was performed by measuring the amplitude at 310 nm after applying first derivative to the measured zero order spectra. The obtained results proved that the method can be employed for the routine analysis of the drugs.
