The prevalence of hyperuricemia has been increasing both in developing and developed countries. The purpose of the present study was to investigate the prevalence of hyperuricemia and the association between SUA. This is the cross sectional study among patients of outpatient department (OPD) of Universal College of Medical Sciences Teaching Hospital, Bhairahawa, Lumbini zone, Nepal who have attended for medical checkup. Serum uric acid was estimated by uricase/PAP method. Overall prevalence of hyperuricemia among the total population (3520) was 17.38%. Among the hyperuricemic population, the prevalence was 17.20% in men and 23.64% in women. In different age groups of age < 20 years to age >70 years; hyperuricemia in men and women were 9.62%, 7.62±0.46 to 29.12%, 8.56±1.30 and 14.4% 6.81±0.85 to 31.3%, 6.84±0.68 respectively. prevalence of hyperuricemia was high among these populations of Lumbini zone. Hyperuricemia may be considered as an independent indicator. It may enhance the risk for getting diseases.