A series of novel sulfonamides fused with Betti’s bases were synthesized and all the synthesized compounds were subjected to molecular docking study against DNA topoisomerase II as it was found to be the target for some of the most active anticancer agents. On the basis of the results obtained from docking studies we concluded that some of the synthesized novel sulfonamide derivatives might show significant anticancer activity by inhibiting DNA topoisomerase II.
