Diclofenac and Propolis based scaffolds were compared for their in vitro drug delivery efficacy. The fabricated Gelatin scaffolds were then soaked in Diclofenac and Propolis followed by thorough drying. The drug loaded scaffolds were tested for their anti-microbial and anti-fungal efficiency. The scaffolds loaded with the two different drugs were also subjected to drug release analysis in vitro. Propolis was found to possess a controlled release pattern when compared to that of Diclofenac.