The isoxazole ring is a universal centroid of many synthetic compounds with various therapeutic efficacies. The ongoing review deals with some of the advancement during the last few decades in medicinal chemistry research of isoxazole derivatives as anticonvulsant, antibacterial, antidepressants, antitumor, antithrombin, antirhinovirus etc. The structure activity relationships (SARs) study of many isoxazole analogues have been discussed in such a manner, that it will definitely attract budding researchers to start up a novel medicinal chemistry project considering this sought after scaffold.
