In the present study, quantitative structure activity relationship study was performed on a series of novel quinazolinone derivatives as antitubercular agents using Chem Office ultra 7.0. Multiple linear regression analysis was performed to derive quantitative structure activity relationship models which were further evaluated internally as well as externally for the prediction of activity. The quantitative structure activity relationship evaluation involved a study on thirty four different models; few of them have shown considerable F value. This study indicates that descriptors (logP, ovality, bend energy, partition coefficient and diameter) play an important role for the activity. The data obtained from this present quantitative structure activity relationship study may be useful in the design of more potent substituted quinazolinone derivatives.
