Various 2-Amino-N-(7-subtituted Benzo [d] thiazol-2yl) benzamide containing different secondary amines have been synthesized by treating aniline with KSCN in presence of bromine in glacial acetic acid and ammonia to get to get 2-aminobenzothiazole which was treated with anthranillic acid in presence of dry pyridine to get N- (Benzo [d] thiazol-2-yl) benzamide. To the above appropriate amine in equimolar Quantities were refluxed for 2-6 hrs in an oil bath in the Presence of DMF to get colorless crystalline Derivatives 3 A-E. The derivatives were characterized by melting point, IR, 1HNMR, and mass spectral studies. The compounds were tested for antimicrobial activity against Staphylococcus aureus (MTCC 83), Streptococcus pyogen (MTCC 442), Escherichia coli (MTCC443), Pseudomonas aeruginosa (MTCC 741), Aspergillus niger (MTCC 134), Candida albicans (MTCC 183) taking Ceftizoxime, Ampilicilline, Gentamicin and Fluconazole as standard drugs and showed significant activity.
