Preeclampsia is a pregnancy-specific disorder. In this study, the impact of Silymarin was investigated on antioxidant capacity of serum and lipid peroxidation in patients with severe pre-eclampsia.60 patients whose pregnancy were ended because of severe preeclampsia were entered the study. Patients were randomly divided into two groups of 30case and control groups. In addition to current treatments for preeclampsia, case groups were administered 70 mg of Silymarin, 3 and 24 hours after the termination of pregnancy. The control group received placebo at the same time. Antioxidant capacity of serum and lipid peroxidation was checked60 hours after the termination of pregnancy in two groups. At the baseline, the two groups were not significantly different in terms of criteria such as age, BMI. Peroxidation of lipids in maternal serum 60 hours after the termination of pregnancy were not significantly different in the two case and control groups (P>0.05).Antioxidant capacity in maternal serum were significantly different in the two case and control groups. Silymarin is an herbal remedy that in many cases has beneficial results. It seems that this drug can be used in severe pre-eclampsia. However, as the risk of severe pre-eclampsia can predict long-term cardiovascular complications for the mother, design of studies with long-term use of antioxidant in pregnant women with severe preeclampsia and its long-term follow-up is recommended.
