Difficulties in measuring insulin sensitivity prevent the identification of insulin-resistant individuals in the general and obese population. Therefore, we compared fasting insulin, homeostasis model assessment (HOMA), insulin-to-glucose ratio, Bennett index, and a score based on weighted combinations of fasting insulin, BMI, and fasting triglycerides with the euglycemic insulin clamp to determine the most appropriate method for assessing insulin resistance in the obese south Indian population. We measured insulin sensitivity (as the whole body insulin-mediated glucose uptake) and fasting post hepatic insulin delivery rate (IDR) with the use of the euglycemic insulin clamp technique in a large group of obese subjects in the database of the European Group for the Study of Insulin Resistance. Insulin resistance, defined as the lowest decile of insulin sensitivity in the lean subgroup. In the obese with preserved insulin sensitivity, risk for diabetes, cardiovascular risk, and response to treatment may be different than in insulin resistant obesity. As Asian Indians have an increased susceptibility to diabetes and have increased insulin resistance, they are a unique population for carrying out genetic studies. In this Study all the subjects were diagnosed as per the American Diabetes Association criteria based on fasting and post lunch blood glucose levels.
