The prenyloxy chalcones were synthesized by piperidine mediated condensation of an ethanolic solution of a 4- prenyloxy 2-hydroxy acetophenone with aromatic or hetero aldehydes and corresponding prenyloxy flavanones also were obtained from mixture of the prenyloxy chalcone and flavanone was subjected to column chromatography over silica-gel. In this article, mainly explained structural elucidations of newly synthesized compounds along with the brief description of the targets and reported piperidine mediated synthesis. The piperidine is planned to use a weaker base instead of strong base to enhance the better yields. The structures of the compounds have been established on the basis of elemental (C, H, and O) analysis and IR, 1H NMR, MS spectral data. Synthesized compounds were screened for comparative study of cytotoxic analysis.
