Acorus calamus Linn. is a herbaceous plant with rhizome that is indefinite branched, smooth, pinkish or pale green.The leaf and rhizome part of Acorus Calamus possess antibacterial activity. Ocimum kilimandscharicum is a short herb, native to India. In traditional medicine, it is used to treat various ailments including colds, coughs, abdominal pains, measles and diarrhoea.The present study was to study the basic properties of Acorus calamus and Ocimum kilimandscharicum leaf extracts and to formulate a simple syrup and studying its activity on pathogens.The aqueous extracts of the leaves were studied for their total protein, free phenolic and hydroxyl free radical scavenging activity.The extracts and prepared syrup were tested for their antimicrobial activity against P.aragenosa, B.cereus, E.coli and N.meningitis. Both the prepared formulations were evaluated for various parameters such as pH, appearance, colour, odour and taste. We found that both the extracts possessed excellent antioxidant and antibacterial activity. The formulated syrup too was found to be effective on clinical pathogens