Introduction: Hepatitis B is a major health problem in the world and Iran. Vaccination is the best way to prevent this disease. The risk of transmission among health care workers is more than other people in community. Therefore, the aim of this study was to determine the efficacy of hepatitis B vaccine among health personnel working in a hospital in West of Iran. Materials and Methods: A cross-sectional study was conducted in the 2014, on 104 voluntary personnel from different sections of the hospital. After hospital ethical committee clearance, subjects have vaccinated three times were selected. The antibody titer level as an indicator vaccination effectiveness, was measured using ELISA test. Demographic information was recorded in a author-made questionnaire that its validity and reliability was confirmed by experts. The independent t-test was used to determine the relationship between antibody titer and age, the analysis of variance was applied do define its relation with the other variables. Linear regression was used to test the relationship with age, antibody titer levels and Body Mass Index. Data were analyzed using SPSS software Ver: 14. Results: The mean antibody titers level was 312. 45 mIU / mL and 208.64 mIU / mL in men and women respectively. Protection level of the subjects were 79.41% >100 mIU / ml, 13.73% , 11-100 mIU / mL and 6.86%, 0-10 mIU / mL based on antibody titer level respectively. Conclusion: In our study, most of the worker level antibody titer were in protectable reneges. we found significant Correlation between level antibody titer and imitation of vaccination time and gender
