The present research has been undertaken with the aim to design, formulate and evaluate the polyherbal Tridax procumbens based cream comprising of Aloe vera, Marigold, Henna, Papaya and Neem. The cream was evaluated for pharmaceutical parameters & wound healing activity. The cream was formulated using accurately weighed amount of drug extract along with base and other suitable additives. The pH of all the formulations were checked and found to be compatible with the normal pH range of the skin. The formulation showed good spreadability, homogeneity, consistency, there was no change in the appearance and no phase separation was noticed. The cream was evaluated for wound healing activity as period of contraction and tensile strength using excision wound model. Albino wistar rats were divided into 5 groups where betadine ointment was used as reference standard, one served as positive control (ointment base), one negative control and the other two as treated groups. In the model, the rate of wound contraction was accused as healing parameter at every third day. The result showed that topical application of cream increases the percentage of wound contraction and decreases epithelization time in treatment group as compared to other groups which may be due to additive activity of the phytoconstituents present in the extract and hence, may be used as a potential herbal formulation for wound healing.
