A Simple, specific, rapid, precise and accurate UV Spectrophotometric method have been developed and Validated for determination of Metoprolol Succinate. Drug Metoprolol Succinate showed the absorption maxima in at 222 nm and was linear for a range of 5 µg/ml –25 µg/ml with correlation coefficient of 0.9993. The validation of the above proposed method was done by carrying out precision and accuracy studies. The percentage recovery at three different levels i.e. 50%, 100% and 150% was found to be 49.8%, 99.5% and 151.5% respectively. The analytical method showed good Intra precision (Repeatability) with relative standard deviation 0.672 % and Inter precision with relative standard deviation is 0.685% which is less than 2. The proposed method was validated for the parameter Specificity, Precision, Linearity and range, Ruggedness, Accuracy and recovery. Hence proposed analytical method for estimation of Metoprolol Succinate formulation drug by UV spectrophotometer in pharmaceutical can be applied for the routine quality control analysis.
