Research
Dulaglutide Improves Aluminum Chloride Induced Cognitive Dysfunction in Diabetes Associated Alzheimer’s Rat Model
Author(s): VKK Mandlem*, Vazra Sravani K, GSN Koteswara Rao, Ravi Manne and Ramoji Kosuru
Background: Type-2 diabetes is an etiological factor for Alzheimer’s. GLP-1 analogues were prescribed in treating type-2 diabetes mellitus, where the presence of GLP-1 receptors in brain also makes it a potential target for Alzheimer’s disease.
Aim: The aim of the study is to evaluate the neuroprotective effect of dulaglutide in aluminum chloride induced cognitive dysfunction in type-2 diabetes associated Alzheimer’s experimental rats by conducting behavioral studies, estimating the biochemical parameters and histopathological changes involved in the pathogenesis of the disease.
Objective: To evaluate the effect of GLP-1 analogue on learning and memory in Aluminum chloride induced Alzheimer’s disease in type-2 diabetic rats by using physical and biochemical methods.
Methods.. Read More»
DOI:
10.4172/ 0976-1233.004
