Research
Devising a Multi Epitope Vaccine towards the Dengue Virus using the Computational Method in Asian Region
Author(s): Sajidur Rahman Akash, Md Imran Hossain and Md Sarafat Ali*
Dengue is one of the major mosquito-borne diseases that still threaten humans and kill countless people. It is caused by a
positive-stranded RNA virusthat included the family of Flaviviridae. Dengue fever is an exquisite feverish viral disease
dispatched by Aedes mosquitoes? sting, posing any one of the four dengue viral serotypes. This virus transmits through
a vertical transmission way using a full unique system. Unfortunately, there is no still effective developed vaccine to
eradicate this disease. Computational methods were used in this work to build and we suggest a multi-epitope vaccination
for the dengue virus in Asia. Epitope conservation was taken into account because Dengue virus is an RNA virus, and all
selected epitopes were 100% conserved. Antigenicity of the final multi-epitope vaccine component was 0.7055. Disulfide
engineering was conducted at an area of high mobil.. Read More»
DOI:
10.4172/0976-1233.005
