Synthesis and characterization of some new thiazolidinones containing coumarin moiety and their antimicrobial study 

By Divyesh Patel, Premlata Kumari, Navin Patel Divyesh Patel 

ABSTRACT

A series of novel thiazolidinones have been synthesized by reaction of various Schiff bases of coumarin with thioglycolic acid. The reaction of 4-hydroxy coumarin with POCl3 yielded 4-chloro coumarin 2 and 4-chloro-3, 4', 3', 4"-tercoumarin 2a. Compound 2 was reacted with p-phenylene diamine to yield 4-[(4-aminophenyl)amino]-2H-chromen-2-one.Various Schiff bases of coumarin were synthesized by condensation of 4-[(4-aminophenyl)amino]-2H- chromen-2-one with different aldehydes. The structures of the newly synthesized compound were confirmed by IR, 1H NMR,   13C NMR and C, H, N analysis. The thiazolidinone derivatives were evaluated for their anti bacterial and antifungal activity by broth dilution method. 

Keywords: Coumarin, Schiff bases, thiazolidinone, antibacterial, antifungal. 

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