Synthesis and antibacterial activity of some new triazole derivatives

By Sumitra Chanda, Yogesh Baravalia and Shipra Baluja


The present communication deals with synthesis of some new triazole derivaties, their characterization and antibacterial activity against some medically important bacteria. The antibacterial activity was studied against E. coli (ATCC 25922), P. aeruginosa (ATCC 27853), S. aureus (ATCC 25923), B. cereus (ATCC 11778), A. fecalis (ATCC 8750), K. pneumoniae (NCIM 2719).  The antibacterial activity in two solvents (1,4-Dioxan and DMF) was evaluated using Agar Ditch method.  A differential effect of the compounds was found in the bacterial strains investigated and the solvents used, again suggesting that the antibacterial activity is dependent on the molecular structure of the compound, solvent used and the bacterial strains under consideration. In the present work, B. cereus appeared to be most susceptible bacteria while P. aeruginosa was the most resistant bacterial strain.


Key words: antibacterial activity, triazole compounds, polar and non polar solvents


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