Evaluation of genotoxic and Green chemistry approach for synthesis of 5-arylidine barbituric acid derivatives by hydrotrope induced Knovenagel condensation in aqueous medium
potential of Croton bonplandianum Baill

By Santosh Kamble, Gajanan Rashinkar, Arjun Kumbhar, Kavita Mote and Rajashri Salunkhe


An efficient Knovenagel condensation of babituric acid with different aromatic aldehyde in aqueous hydrotropic solution affording the corresponding 5-arylidine barbituric acid derivatives in very short time of reaction with high yield and  purity.


Key Words : Knovenagel condensation, alternative solvents, hydrotropes.

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