Synthesis and characterization of some arylamino derivatives of chloroquinoline as antimicrobial agents

By Bhimani Kanji B., Khunt Ranjan C., Sangani Harhsad G., Dhol Snehal R., Detroja Dilip P., Parikh Arun R.

Abstract

Substituted Schiff’s bases (2a-m) have been prepared by the treatment of 2-chloro-6-methxoyquinoline-3-carbaldehyde (1) with different arylamines, which on reaction with NaBH4 furnish our target molecule (3a-m). The structures of the synthesised compounds have been assigned on the basis of elemental analyses, IR, NMR and mass spectral studies. The compounds were evaluated for antimicrobial screening against Gram positive & Gram negative bacteria and fungal strain such as Aspergillus niger. Most of the compounds showed significant activity against all the species of bacteria and fungi.

 

Key Words : Aryl amines, 2-chloro-6-methoxyquinoline-3-carbaldehyde and antimicrobial activity..

 

Click here to download the complete article in PDF Format