The role of nanodrugs for targeted drug delivery in cancer treatment

By Sweta Gupta, Brijesh Singh Yadav, Rajesh Kesharwani, K. P. Mishra, N. K. Singh

Abstract

Nanotechnology has achieved the status as one of the critical research endeavors of the early 21st century. Nanoscale devices and components are smaller than human cells (10,000–20,000 nm in diameter) & organelles and similar in size to large biological macromolecules such as enzyme & receptors – Hb for e.g., is approx 5 nm in diameter. While the lipid bilayer surrounding the cells are on the order of 6 nm thick. Nanoscale devices are smaller than 50 nm can easily enter most cells, while those smaller than 20 nm can transit out of blood vessels. Therefore, the size of the Nanoscale devices allows them to interact readily with biomolecules on the cell surface and within the cell, often in ways that do not alter the behavior and biochemical properties of those molecules. Such ready access to the interior of a living cell affords the opportunity for unprecedented gains on the clinical and basic frontiers. Nanotechnology research is generating a variety of constructs giving cancer researchers great flexibility in their efforts to change the paradigm of cancer diagnosis, treatment, and prevention. In this study we focused how Cancer Nanotechnology is to develop safer and more effective diagnostic and therapeutic modalities for Cancer therapy.

 

Key Words : Nanotechnology, nanoscale devices, lipid bilayer, cancer therapy

 

Click here to download the complete article in PDF Format